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Call your doctor right away for further instructions if you get dehydrated (lose a large amount of body fluids).

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When methotrexate is administered concomitantly with other hepatotoxic agents such as azathioprine, retinoids or sulfasalazine, there is the potential for increased hepatotoxicity.

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Second, there should be no drastic effects of going off mtx cold turkey.

These results imply that TNF-α has a critical role in the clinical manifestations of rheumatoid arthritis as well as in the progressive bone and cartilage damage.

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Tell your doctor if you or your sexual partner become pregnant during treatment.

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Prophylaxis: dosage is the same as for treatment; administration intervals differ from regimen used in treatment.

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Skin: Severe, occasionally fatal, dermatologic reactions, including toxic epidermal necrolysis, Stevens-Johnson syndrome, exfoliative dermatitis, skin necrosis, and erythema multiforme, have been reported in children and adults, within days of oral, intramuscular, intravenous, or intrathecal methotrexate administration.

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Methotrexate may cause a severe rash that can be life-threatening.

The patients also had to have entered remission after treatment with 25 mg of methotrexate once weekly by intramuscular injection for a minimum of 16 weeks.

Doses should not exceed 20 mg per week, especially in children treating juvenile rheumatoid arthritis.

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Blood cultures should be obtained during the work-up of the arthritis, as they may become positive before the synovial fluid cultures.

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