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The COPE trial demonstrated that colchicine was effective in preventing recurrent pericarditis if given after the first episode of acute pericarditis, and the Colchicine for Recurrent Pericarditis (CORE) trial demonstrated that colchicine was effective in preventing relapses when given after the first episode of recurrent pericarditis.

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It also has been studied in other In addition, an earlier study performed by Imazio and colleagues -- known as the -- found that adding colchicine to conventional treatment cut the rate of pericarditis recurrences in half, the investigators noted.

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The long term use of colchicine is established for FMF and the prophylaxis of gout flares but the safety and efficacy of repeat treatment for gout flares has not been evaluated.

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