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Antibiotics. For moderate to severe acne, you may need oral antibiotics to reduce bacteria and fight inflammation. Usually the first choice for treating acne is tetracycline — such as minocycline or doxycycline — or a macrolide. Oral antibiotics are best used with topical retinoids and benzoyl peroxide.
How long does it take for acne to clear up?
Give an acne treatment at least 4 weeks to work. Acne treatment needs time to work. Using a different product every few days can also irritate your skin, causing new breakouts. If a treatment works for you, you should notice some improvement in 4 to 6 weeks. It can take two to three months or longer to see clearing.