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I have been on Depo for 11 years now. I had about a month of spotting when I got my 1st injection, but I have since stopped having periods altogether. It has NOT affected my sex drive. I have gained a little weight, but that could also just be the fact that my metabolism has slowed since I'm getting older. In the last year I have had a little bone loss and my doctor now wants me to switch to something else. She has suggested Implanon. Wish I could just stay on Depo.
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I have been on Depo Provera since I was 18, so about five years. I have had no issues with it. I have not had a period in years (before I had terribly heavy periods), I did not experience any weight gain, do not have trouble staying fit, and do not experience any mood/personality swings. I just don't like that it's likely weakening my bones, but I try to stay on top of that with calcium/D supplements. However, I do wonder if it's had a negative effect on my sex drive, but that's inconsistent and I have nothing to compare it to since I got my shot as soon as I became sexually active, so it's hard to say.

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